Cobicistat

Cobicistat
Systematic (IUPAC) name
Thiazol-5-ylmethyl N-[1-benzyl-4-[[2-[[(2-isopropylthiazol-4-yl)methyl-methyl-carbamoyl]amino]-4-morpholino-butanoyl]amino]-5-phenyl-pentyl]carbamate
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 1004316-88-4
ATC code  ?
ChemSpider 25084912 YesY
UNII LW2E03M5PG YesY
Chemical data
Formula C40H53N7O5S2 
Mol. mass 776.023 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Cobicistat is a drug under experimental investigation for use in the treatment of infection with the human immunodeficiency virus (HIV).

Like ritonovir (Norvir), cobicistat is of interest not for its anti-HIV properties, but rather its ability to inhibit liver enzymes that metabolize other medications used to treat HIV, notably elvitegravir, an HIV integrase inhibitor currently under investigation itself. By combining cobicistat with elvitegravir, higher concentrations of elvitgravir are achieved in the body with lower dosing, theoretically enhancing elvitgravir's viral suppression while diminishing its adverse side-effects. In contrast with ritonavir, the only currently approved booster, cobicistat has no anti-HIV activity of is own.[1]

If approved by the U.S. Food and Drug Administration, cobicistat will be part of the four-drug, fixed-dose combination HIV treatment known as the "Quad Pill".[1][2] The Quad Pill is currently in Phase III clinical trials,[3] and is owned by Gilead Sciences.

References

  1. ^ a b Highleyman, L. Elvitegravir "Quad" Single-tablet Regimen Shows Continued HIV Suppression at 48 Weeks. HIV and Hepatitis.com
  2. ^ R Elion, J Gathe, B Rashbaum, and others. The Single-Tablet Regimen of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate (EVG/COBI/FTC/TDF; Quad) Maintains a High Rate of Virologic Suppression, and Cobicistat (COBI) is an Effective Pharmacoenhancer Through 48 Weeks. 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2010). Boston, September 12–15, 2010.
  3. ^ "Quad Pill Phase III Clinical Trials". ClinicalTrials.gov. http://clinicaltrials.gov/ct2/results?term=elvitegravir+GS-9350+OR+cobicistat&phase=2. Retrieved August 2011. 

Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • Antirretroviral — Los fármacos antirretrovirales son medicamentos para el tratamiento de la infección por el retrovirus VIH, causante del sida. Diferentes antirretrovirales actúan en varias etapas del ciclo vital del VIH. Varias combinaciones de 3 o 4 fármacos se… …   Wikipedia Español

  • Elvitégravir — Général Nom IUPAC acide 6 (3 ch …   Wikipédia en Français

  • Zidovudine — AZT redirects here. For other uses, see AZT (disambiguation). Zidovudine Systematic (IUPAC) name …   Wikipedia

  • Antiretroviral drug — HAART redirects here. For UK estate agency Haart, see Spicerhaart. Antiretroviral drugs are medications for the treatment of infection by retroviruses, primarily HIV. When several such drugs, typically three or four, are taken in combination, the …   Wikipedia

  • Didanosine — Systematic (IUPAC) name 9 [(2R,5S) 5 (hydroxymethyl)oxolan 2 yl] 6,9 dihydro 3H purin 6 one Clinical data AHFS/Drugs.c …   Wikipedia

  • Zalcitabine — Systematic (IUPAC) name 4 amino 1 ((2R,5S) 5 (hydroxymethyl)tetrahydrofuran 2 yl)pyrimidin 2(1H) one Clinical data AHFS/Drugs.com …   Wikipedia

  • Stavudine — Systematic (IUPAC) name 1 ((2R,5S) 5 (hydroxymethyl) 2,5 dihydrofuran 2 yl) 5 methylpyrimidine 2,4(1H,3H) dione Clinical data AHFS/Drugs.com …   Wikipedia

  • Emtricitabine — Systematic (IUPAC) name 4 amino 5 fluoro 1 [(2S,5R) 2 (hydroxymethyl) 1,3 oxathiolan 5 yl] 1,2 dihydropyrimidin 2 one Clinical data …   Wikipedia

  • Ritonavir — Systematic (IUPAC) name 1,3 thiazol 5 ylmethyl N [(2S,3S,5S) 3 hydroxy 5 [(2S) 3 methyl 2 {[methyl({[2 (propan 2 yl) 1,3 thiazol 4 yl]methyl})carbamoyl]amino}butanamido] 1,6 diphenylhexan 2 yl]carbamate …   Wikipedia

  • Nevirapine — Systematic (IUPAC) name 11 cyclopropyl 4 methyl 5,11 d …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”