Cysteamine

Cysteamine
Cysteamine
Identifiers
CAS number 60-23-1 YesY, 156-57-0 (HCl)
PubChem 6058
ChemSpider 5834 YesY
UNII 5UX2SD1KE2 YesY
DrugBank DB00847
KEGG D03634 YesY
ChEBI CHEBI:17141 YesY
ChEMBL CHEMBL602 YesY
Jmol-3D images Image 1
Properties
Molecular formula C2H7NS
Molar mass 77.15 g mol−1
Melting point

95-97 °C

Hazards
MSDS External MSDS
EU classification Harmful Xn
S-phrases S26 S36
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Cysteamine is the chemical compound with the formula HSCH2CH2NH2. It is the simplest stable aminothiol and a degradation product of the amino acid cysteine. It is often used as the hydrochloride salt, HSCH2CH2NH3Cl.

Biochemical and pharmaceutical applications

Under the trade name Cystagon, cysteamine is used in the treatment of disorders of cystine excretion. Cysteamine cleaves the disulfide bond with cystine to produce molecules that can escape the metabolic defect in cystinosis and cystinuria.

It is also used for treatment of radiation sickness.[1]

Cysteamine is used in the body to form the essential biochemical coenzyme A by combining with pantothenate and adenosine triphosphate.

In 2008, Raptor Pharmaceuticals started phase II clinical trials testing a delayed release (DR) preparation of cysteamine bitartrate for Huntington's disease. DR Cysteamine is also being investigated as a treatment for cystinosis, Batten disease, and non-alcoholic steatohepatitis.

References

  1. ^ Lukashin BP, Grebeniuk AN (2001). "[Comparative study of the radiation-protective effectiveness of low doses of cysteamine, heparin, and naphtizine in experiments on mice]" (in Russian). Radiatsionnaia biologiia, radioecologiia / Rossiĭskaia akademiia nauk 41 (3): 310–2. PMID 11458646. 

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Look at other dictionaries:

  • Cysteamine — Cystéamine Cystéamine Général Nom IUPAC 2 aminoéthanethiol No CAS …   Wikipédia en Français

  • Cystéamine — Général Nom IUPAC 2 aminoéthanethiol No CAS …   Wikipédia en Français

  • cysteamine — merkaminas statusas T sritis chemija formulė HSCH₂CH₂NH₂ atitikmenys: angl. cysteamine; mercamine rus. меркамин; цистеамин ryšiai: sinonimas – cisteaminas sinonimas – 2 aminoetantiolis …   Chemijos terminų aiškinamasis žodynas

  • Cysteamine dioxygenase — Identifiers EC number 1.13.11.19 CAS number 9033 41 4 …   Wikipedia

  • cysteamine bitartrate — the bitartrate salt of cysteamine, with uses similar to those of the base …   Medical dictionary

  • cysteamine hydrochloride — the hydrochloride salt of cysteamine, with uses similar to those of the base …   Medical dictionary

  • cysteamine — noun Etymology: cysteine + amine Date: 1943 a cysteine derivative C2H7NS used especially to treat cystinuria …   New Collegiate Dictionary

  • cysteamine — noun The simplest stable aminothiol, a degradation product of the amino acid cysteine, used to treat cystine excretion disorders and radiation sickness …   Wiktionary

  • cysteamine — Sulfhydryl compound used experimentally to produce ulcers in rats and as a radioprotective agent; antidote to acetaminophen. * * * cys·te·amine sis tē ə mən n a cysteine derivative used in the form of its bitartrate C2H7NS·C4H6O6 to treat… …   Medical dictionary

  • cysteamine — cys·te·amine …   English syllables

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