Élan

Élan

Infobox_Company | company_name = Élan Corporation plc|
company_type = Public
company_slogan = ?
foundation = flagicon|IRL Athlone, County Westmeath, Ireland (1969)
location = flagicon|IRL Dublin 2, Dublin, Ireland
key_people = Kelly Martin, President & CEO
Paul Breen, Global Services & Operations
Richard T. Collier, General Counsel
Shane Cooke, Chief Financial Officer
William Daniel, Company Secretary
Lars Ekman, Global R&D and Corporate Strategy
Jack Laflin, Global Core Services
Ivan Lieberburg, Chief Medical Officer
industry = Biotechnology
num_employees = 2,000 (2004)
products = PRIALT (ziconotide)
NANOCRYSTAL technology
In pipeline:
TYSABRI (natalizumab)
AZACTAM (aztreonam for injection, USP)
MAXIPIME (cefepime hydrochloride) for Injection
revenue = loss $464.0 million USD (2004)
homepage = [http://www.elan.com www.elan.com]

Élan Corporation plc (nyse|ELN, lse|ELA) is a major drugs firm based in Athlone, County Westmeath, Ireland which has major interests in the United States. In the late 1990's its value on the Irish Stock Exchange reached over 20bn. It has secondary listings on the London Stock Exchange and the New York Stock Exchange. It was one of Ireland's major business success stories. However in the early years of 2000's an accounting scandal and investor reactions to the global slump, caused a major devaluation resulting in a share price slump of over 90%. Since then the company has regained its growth path under the reign of a new American CEO Kelly Martin. Élan employs over 2,000 people worldwide. It is listed on the New York Stock Exchange as ELN, the Irish Stock Exchange as ELN.I, and the London Stock Exchange as ELN.L. Reformulations for client-based projects has contributed to more than $9 billion in in-market sales for these clients. Currently more than 2.5 million patients take Élan's products worldwide.

Products in development

In neurology, Élan is focused on building upon its breakthrough research and extensive experience in the area of neuropathology-related disorders such as Alzheimer’s disease, where the company’s efforts include programs focused on small molecule inhibitors of beta secretase and gamma secretase, enzymes whose actions are thought to affect the accumulation of the amyloid plaques found in the brains of patients with Alzheimer’s disease. Élan is also studying other neurodegenerative diseases, such as Parkinson's disease. Élan, in collaboration with Wyeth, initiated a Phase II clinical trial for an experimental humanized monoclonal antibody with a targeted indication of immunotherapeutic treatment of mild to moderate Alzheimer’s disease. The humanized monoclonal antibody is designed and engineered to clear the neurotoxic beta-amyloid peptide that accumulates in the brains of patients with Alzheimer’s disease. Élan is hopeful that its drug "aab-001" (now known as bapineuzumab) is doing well in trials as the first results are due in 2006.

In autoimmune diseases, Élan’s primary emphasis is studying cell trafficking to discover ways to provide disease-modifying therapies for autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease. Research efforts are also focused on physiological and neuropathic pain.

Natalizumab/Tysabri

:"See main article: Natalizumab/TysabriPreviously named Antegren, Natalizumab is a drug co-marketed by Biogen Idec and Élan as "Tysabri". Tysabri is a monoclonal antibody that inhibits immune cells from crossing blood vessel walls to reach various tissues, including the brain. It has proven efficacy in the treatment of two serious autoimmune disorders: multiple sclerosis, and Crohn's disease. In multiple sclerosis, Tysabri was shown to reduce relapses by 67% vs. a placebo in double-blind studies. It slowed the progression of disability by 42%. While it is impossible to compare results across different clinical trials, the older generation drugs, i.e. interferons and Copaxone, are generally acknowledged as demonstrating about a 30-35% decrease in relapse rate vs. placebo; and only two drugs have been shown to decrease the progression of disability, but again only by around 20-40%.

Drug delivery

Elan has developed novel drug delivery systems including its nanocyrstal technology and oral controlled release formulations of drug delivery.

NanoCrystal Technology

For poorly water soluble compounds, Élan's proprietary NanoCrystal technology can enable formulation and improve compound activity and final product characteristics. The NanoCrystal technology can be incorporated into all dosage forms both parenteral and oral, including solid, liquid, fast-melt, pulsed release and controlled release dosage forms.

Drugs

Products and drugs that Élan has developed include:
*Avinza – once-daily, novel dual release morphine sulphate
*Emend – oral table form of aprepitant, a poorly water soluble compound
*Focalin XR – once-daily dexmethylphenidate marketed in US and other territories
*Herbesser R – once-daily, high-potency, sustained release diltiazem for Japanese and other Asian markets
*Megace ES – concentrated oral suspension utilizing NanoCrystal Technology, marketed in the U.S.
*NaprÉlan - once-daily, sustained-release naproxen sodium
*Rapamune - oral tablet form of poorly water soluble compound
*Ritalin LA – once-daily, pulsatile release of methylphenidate
*Theo-Dur - twice-daily, sustained-release theophylline
*TriCor - new formulation of Abbott’s fenofibrate, which can be taken without regard to food, launched in the U.S.
*VerÉlan - once-daily, sustained-release verapamil
*VerÉlan PM – modified release, chronotherapeutic verapamil

References

* [http://www.nyas.org/ebriefreps/ebrief/000546/presentations/schenk/player.html]

External links

* [http://elan.com/ Élan's homepage]


Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • élan — élan …   Dictionnaire des rimes

  • Élan — Pour les articles homonymes, voir Élan (homonymie), Éland et L Orignal …   Wikipédia en Français

  • Elan — may refer to:Computer related: *ELAN, an emulated LAN *Elan, another name for the 1980s Enterprise 128 home computer *Elan Graphics, computer graphics subsystem for mid 1990s Silicon Graphics workstations *Elan programming language, an… …   Wikipedia

  • Elan — bezeichnet: Elan Valley, Gebiet in Wales Elan (Pruth), Nebenfluss des Pruth ELAN, Programmiersprache Elán, slowakische Rockgruppe Elan (Unternehmen), slowenischer Skihersteller Elan Corporation, irisch amerikanische Biotechfirma Lotus Elan, ein… …   Deutsch Wikipedia

  • élan — 1. (é lan) s. m. 1°   Mouvement pour s élancer. Il prit son élan. L élan qu il avait le fit tomber. •   Il partit comme un trait, mais les élans qu il fit Furent vains...., LA FONT. Fabl. VI, 10.    N avancer que par élans, avancer par des… …   Dictionnaire de la Langue Française d'Émile Littré

  • Elán — Pays d’origine  Slovaquie …   Wikipédia en Français

  • Elan — Saltar a navegación, búsqueda Elan puede referirse a: Automóviles: Elan (Marca), marca eslovena de artículos deportivos. Lotus Elan, modelo de los años 60 y años 90 de Lotus Cars. Personajes: Elan, cantante mexicana. Obtenido de Elan Categoría:… …   Wikipedia Español

  • Elan — Sm Schwung, Energie erw. fremd. Erkennbar fremd (18. Jh.) Entlehnung. Entlehnt aus frz. élan, einer lautlich unregelmäßigen Ableitung von frz. élancer vorwärtsschnellen , zu frz. lancer schleudern , aus spl. lanceāre die Lanze schwingen , zu l.… …   Etymologisches Wörterbuch der deutschen sprache

  • elan — èlān (Ø, za što) m <G elána> DEFINICIJA životni poticaj kao osnova stvaranja [imati elana; (raditi) s elanom]; energija, polet, zamah, zanos SINTAGMA élan vital (izg. elȃn vitȃl) fil. životni polet, životni zamah, čovjekova kreativna snaga …   Hrvatski jezični portal

  • Elan — Elan: Elan словенский производитель лыж Lotus Elan серия автомобилей …   Википедия

  • Élan — País …   Wikipedia Español

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”