Allobarbital

Allobarbital
Allobarbital
Systematic (IUPAC) name
5,5-diprop-2-enyl-1,3-diazinane-2,4,6-trione
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 52-43-7
ATC code N05CA21
PubChem CID 5842
ChemSpider 5635 YesY
UNII 8NT43GG2HA YesY
KEGG D02817 YesY
ChEMBL CHEMBL267719 YesY
Synonyms 5,5-Diallylbarbituric acid, Allobarbital
Chemical data
Formula C10H12N2O3 
Mol. mass 208.214 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Allobarbital is a barbiturate derivative invented in 1912 by Ernst Preiswerk and Ernst Grether working for CIBA. It was used primarily as an anticonvulsant [1] although it has now largely been replaced by newer drugs with improved safety profiles. Other uses for allobarbital included as an adjutant to boost the activity of analgesic drugs, and use in the treatment of insomnia and anxiety.

Allobarbital was never particularly widely used compared to better known barbiturates such as phenobarbital and secobarbital, although it saw more use in some European countries such as Bulgaria and Slovakia,[2] and is still used in for example Poland, but only as compound[3].


References

  1. ^ Chocholova L, Radil-Weiss T. Effect of allobarbital on focal epilepsy in rats. Physiologia Bohemoslovaca. 1971;20(4):325-34.
  2. ^ Getova D, Georgiev V. GABA-ergic mechanisms in the anticonvulsive activity of newly-synthesized barbiturates. I. Effects of barbiturates on the convulsive action of GABA-antagonists. Acta Physiologica et Pharmacologica Bulgarica. 1987;13(3):43-50.
  3. ^ http://www.domzdrowia.pl/29439,apteczka-babuni-krople-zoladkowe-krople-20-g.html

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Look at other dictionaries:

  • allobarbital — [a(l)lobaʀbital] n. m. ÉTYM. XXe; de allo , barbit(urique), et suff. al. ❖ ♦ Pharm. Médicament barbiturique à action hypnotique rapide, administré par la bouche …   Encyclopédie Universelle

  • Allobarbital — Strukturformel Allgemeines Freiname Allobarbital Andere Namen …   Deutsch Wikipedia

  • allobarbital — noun An early barbiturate once used as an anticonvulsant …   Wiktionary

  • allobarbital — A hypnotic with an intermediate to long duration of action. * * * al·lo·bar·bi·tal .al ə bär bə .tȯl n a white crystalline barbiturate C10H12N2O3 used as a sedative and hypnotic called also diallylbarbituric acid …   Medical dictionary

  • allobarbital — al·lo·bar·bi·tal …   English syllables

  • allobarbital — …   Useful english dictionary

  • Barbiturat — Barbiturate sind Derivate der Barbitursäure, allerdings keine Salze oder Ester, wie der Name suggeriert. Die Substituenten sind allesamt mittels Knoevenagel Kondensation an das α C der Malonsäure gebunden. Barbitursäurederivate waren für viele… …   Deutsch Wikipedia

  • Schlaferzwinger — Barbiturate sind Derivate der Barbitursäure, allerdings keine Salze oder Ester, wie der Name suggeriert. Die Substituenten sind allesamt mittels Knoevenagel Kondensation an das α C der Malonsäure gebunden. Barbitursäurederivate waren für viele… …   Deutsch Wikipedia

  • Sodium thiopental — Systematic (IUPAC) name …   Wikipedia

  • Propofol — Systematic (IUPAC) name 2,6 diisopropylphenol …   Wikipedia

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