Methyllysine

Methyllysine


In proteins, the amino acid residue lysine can be methylated once, twice or thrice on its terminal sidechain ammonium group.

Such methylated lysines play an important role in epigenetics; the methylation of specific lysines of certain histones in a nucleosome alters the binding of the surrounding DNA to those histones, which in turn affects the expression of genes on that DNA. The binding is affected because the effective radius of the positive charge is increased (methyl groups are larger than the hydrogen atoms they replace), reducing the strongest potential electrostatic attraction with the negatively charged DNA. Moreover, the methyl groups are themselves hydrophobic, and alter the structure of water in their vicinity, similar to tetramehtyl ammonium (Jencks reference).

In Protein Data Bank files, methylated lysines are indicated by the MLY acronym.



Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • N6-Methyllysine — Diagramme du N(6) methyllisine LeN(6) methyllisine est un acide aminé remanié dans les protéines tout comme son homologue de structure la N(6) trimethyllisine. Présent dans les protéines contractiles et dérivant de la lysine. Acide aminé …   Wikipédia en Français

  • N6-methyllysine — Diagramme du N(6) methyllisine LeN(6) methyllisine est un acide aminé remanié dans les protéines tout comme son homologue de structure la N(6) trimethyllisine. Présent dans les protéines contractiles et dérivant de la lysine. Acide aminé …   Wikipédia en Français

  • N6-méthyllysine — Diagramme du N(6) methyllisine LeN(6) méthyllisine est un acide aminé remanié dans les protéines tout comme son homologue de structure la N(6) trimethyllisine. Présent dans les protéines contractiles et dérivant de la lysine …   Wikipédia en Français

  • N6-methyl-lysine oxidase — Identifiers EC number 1.5.3.4 CAS number 37256 28 3 …   Wikipedia

  • Acetyllysine — Chembox new Reference = [ [http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIGMA/A4021?cm mmc=PubChem public%20database products products Nε Acetyl L lysine] at Sigma Aldrich (contains image of an acetyllysine)] ImageFile=Acetyllysine… …   Wikipedia

  • flagellin — Any member of a class of proteins containing the amino acid, ε N methyllysine; this class represents the main protein component of the flagella of bacteria. * * * fla·gel·lin flə jel ən n a polymeric protein that is the chief …   Medical dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”