HIV Rev response element

HIV Rev response element

The Rev response element (RRE) is a region in the RNA molecule of the HIV env gene. Rev has a nuclear export signal and is essential for the export of the viral RNA out of the nucleus. snRNAs have a nuclear retention signal and prevent unspliced RNA from being exported out of the nucleus. Rev with its nuclear export signal can overcome this nuclear retention signal and thus allows for the export of the RNA even if its introns aren't spliced out.

References

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External links

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* http://www.scripps.edu/mb/millar/research/rev.htm


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