Perinucleolar Compartment

Perinucleolar Compartment

The Perinucleolar Compartment (PNC) is a region of the nucleolus which is inside the nucleus of a cell. The PNC contains large amounts of the hnRNP called hnRNP 1. Many RNA binding proteins are highly enriched in this compartment which requires RNA to maintain its integrity. [Ghetti, A., Pinol-Roma, S., Michael, W.M., Morandi, C. and Dreyfuss G., hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs, Nucl. Acids Res., 20,14,3671-3678,1992,1641332]

The perinucleolar Compartment (PNC) is a subnuclear structure associated with, but structurally distinct from, the nucleolus. The PNC contains large amounts of the hnRNP called hnRNP 1 (PTB). Many RNA binding proteins as well as RNA polymerase III transcripts are highly enriched in this compartment. PTB and pol III transcripts are required for the integrity of the PNC. [1]

References

Links

http://npd.hgu.mrc.ac.uk/compartments/perinuc.html
http://npd.hgu.mrc.ac.uk/search.php?action=builddetails&geneid=1NP00539


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • Cell nucleus — HeLa cells stained for the cell nucleus DNA with the Blue Hoechst dye. The central and rightmost cell are in interphase, thus their entire nuclei are labeled. On the left, a cell is going through mitosis and its DNA has condensed ready for… …   Wikipedia

  • PTBP1 — Polypyrimidine tract binding protein 1, also known as PTBP1, is a human gene.cite web | title = Entrez Gene: PTBP1 polypyrimidine tract binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • Chromatin — The major structures in DNA compaction; DNA, the nucleosome, the 10nm beads on a string fibre, the 30nm fibre and the metaphase chromosome Chromatin is the combination of DNA and proteins that make up the contents of the nucleus of a cell. The… …   Wikipedia

  • Nuclear pore — Diagram of human cell nucleus. Nuclear pore labeled at bottom left …   Wikipedia

  • Nucleolus — The nucleolus is contained within the cell nucleus …   Wikipedia

  • Nucleoplasm — Similar to the cytoplasm of a cell, the nucleus contains nucleoplasm (nucleus sap) or karyoplasm. The nucleoplasm is one of the types of protoplasm, and it is enveloped by the nuclear membrane or nuclear envelope. The nucleoplasm is a highly… …   Wikipedia

  • Nuclear lamina — The nuclear lamina is a dense ( 30 to 100 nm thick) fibrillar network inside the nucleus of a eukaryotic cell. It is composed of intermediate filaments and membrane associated proteins. Besides providing mechanical support, the nuclear lamina… …   Wikipedia

  • Condensin — Condensins are large protein complexes that play a central role in chromosome assembly and segregation in eukaryotic cells. Contents 1 Subunit composition 2 Evolution 3 Subcellular localization and regulation …   Wikipedia

  • Cajal body — Nuclei of mouse cells (blue) containing Cajal bodies (green) visualized by fusion of p80/Coilin protein to GFP. Cajal bodies (CBs) are spherical sub organelles of 0.3 1.0 µm in diameter found in the nucleus of proliferative cells like embryonic… …   Wikipedia

  • Nuclear matrix — In biology, the nuclear matrix is the network of fibres found throughout the inside of a cell nucleus and is somewhat analogous to the cell cytoskeleton. However, in contrast to the cytoskeleton, the nuclear matrix has been proposed to be a… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”