Dolichol kinase

Dolichol kinase
dolichol kinase
Identifiers
EC number 2.7.1.108
CAS number 71768-07-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO
Dolichol kinase
Identifiers
Symbols DOLK; CDG1M; DK; DK1; KIAA1094; SEC59; TMEM15
External IDs OMIM610746 MGI2677836 HomoloGene8940 GeneCards: DOLK Gene
EC number 2.7.1.108
RNA expression pattern
PBB GE DOLK 204488 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 22845 227697
Ensembl ENSG00000175283 ENSMUSG00000075419
UniProt Q9UPQ8 Q8R2Y3
RefSeq (mRNA) NM_014908 NM_177648.3
RefSeq (protein) NP_055723 NP_808316.1
Location (UCSC) Chr 9:
131.71 – 131.71 Mb
Chr 2:
30.14 – 30.14 Mb
PubMed search [1] [2]

In enzymology, a dolichol kinase (EC 2.7.1.108) is an enzyme that catalyzes the chemical reaction

CTP + dolichol \rightleftharpoons CDP + dolichyl phosphate

Thus, the two substrates of this enzyme are CTP and dolichol, whereas its two products are CDP and dolichyl phosphate.

This enzyme belongs to the family of transferases, to be specific, those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is CTP:dolichol O-phosphotransferase. This enzyme is also called dolichol phosphokinase. This enzyme participates in n-glycan biosynthesis.

In humans dolichol kinase is encoded by the DOLK gene.[1][2][3]

Contents

Function

Dolichyl monophosphate is an essential glycosyl carrier lipid for C- and O-mannosylation and N-glycosylation of proteins and for biosynthesis of glycosylphosphatidylinositol anchors in endoplasmic reticulum (ER). Dolichol kinase catalyzes CTP-mediated phosphorylation of dolichol, the terminal step in de novo dolichyl monophosphate biosynthesis.[4]

See also

References

  1. ^ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697. 
  2. ^ Shridas P, Waechter CJ (Oct 2006). "Human dolichol kinase, a polytopic endoplasmic reticulum membrane protein with a cytoplasmically oriented CTP-binding site". J Biol Chem 281 (42): 31696–704. doi:10.1074/jbc.M604087200. PMID 16923818. 
  3. ^ "Entrez Gene: DOLK dolichol kinase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22845. 
  4. ^ Fernandez F, Shridas P, Jiang S, Aebi M, Waechter CJ (September 2002). "Expression and characterization of a human cDNA that complements the temperature-sensitive defect in dolichol kinase activity in the yeast sec59-1 mutant: the enzymatic phosphorylation of dolichol and diacylglycerol are catalyzed by separate CTP-mediated kinase activities in Saccharomyces cerevisiae". Glycobiology 12 (9): 555–62. doi:10.1093/glycob/cwf068. PMID 12213788. 

Further reading

External links



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